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Xinmin Gan Selected Research

amlexanox (Aphthasol)

7/2019A concise synthesis of 3-substituted-7-amino-6-carboxyl-8-azachromones.
1/2019Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes.
11/2018Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.
10/2018Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.

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Xinmin Gan Research Topics

Disease

4Obesity
07/2019 - 10/2018
2Type 2 Diabetes Mellitus (MODY)
01/2019 - 10/2018
2Schizophrenia (Dementia Praecox)
01/2013 - 03/2012
1Weight Loss (Weight Reduction)
11/2018
1Insulin Resistance
10/2018
1Nervous System Diseases (Neurological Disorders)
01/2013
1Cognitive Dysfunction
03/2012
1Mental Disorders (Mental Disorder)
03/2012
1Osteoarthritis
08/2007
1Stroke (Strokes)
08/2007
1Pain (Aches)
08/2007

Drug/Important Bio-Agent (IBA)

4amlexanox (Aphthasol)FDA Link
07/2019 - 10/2018
2Pharmaceutical PreparationsIBA
07/2019 - 10/2018
2Phosphotransferases (Kinase)IBA
11/2018 - 10/2018
1DeuteriumIBA
01/2019
1Carboxylic AcidsIBA
11/2018
1NF-kappaB-Inducing KinaseIBA
11/2018
1benzocycloheptapyridineIBA
11/2018
1Insulin (Novolin)FDA Link
11/2018
1Interleukin-6 (Interleukin 6)IBA
11/2018
1Biological ProductsIBA
11/2018
1KynurenineIBA
01/2013
1EnzymesIBA
01/2013
1TransferasesIBA
01/2013
1kynurenine-oxoglutarate transaminaseIBA
03/2012
1Analgesics (Analgesic Drugs)IBA
08/2007
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
08/2007